The team from the Massachusetts General Hospital carried out tests on brain cells. They found isoflurane boosts the activity of an enzyme called capase, which plays a major part in causing cells to die - a process called apoptosis - and in the development of amyloid protein. Dr Zhongcong Xie, of the Massachusetts General Institute for Neurodegenerative Disease who led the research, said: "Our studies have shown that isoflurane may induce a vicious cycle of apoptosis, amyloid-beta generation, and further rounds of apoptosis. "If future studies support these findings, they suggest that caution be used in choosing this anaesthetic for elderly patients, who already are at increased risk for Alzheimer's and for postoperative cognitive dysfunction."
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